Cancer
Main Findings - Plasma/Serum Lycopene and Disease Risk

Bladder/Breast Cancer | Cervical Cancer | Colorectal Cancer | Endometrial Cancer| Gastric/Oral (Upper GI) Cancer | Lung Cancer | Ovarian Cancer | Pancreatic Cancer | Prostate Cancer

Bladder Cancer- main findings

  • 1 study reported
    • 1 CC study (n=242 cases, CC 1:1)
    • RE: N

Breast Cancer- main findings

  • Data support a neutral relationship between plasma/serum lycopene concentrations and breast cancer risk.
  • The positive (risk) findings require further investigation

Summary of studies and outcomes

  • Number of studies = 11
  • Risk estimates = 11
    • (-) = 5
    • N = 5
    • (+) = 1

Cervical Cancer- main findings

  • Data support a neutral, although potentially protective, relationship between plasma/serum lycopene concentrations and cervical cancer risk.

Summary of studies and outcomes

  • Number of studies = 12
  • Risk estimates = 12
    • (-) = 5
    • N = 7
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 1 (-)
    • √Lyc Lyco = 2 (-)

Colorectal Cancer- main findings

  • Data suggest a protective association between plasma/serum lycopene concentrations and colorectal cancer risk; however, the data are limited, based on number and quality of investigations.

Summary of studies and outcomes

  • Number of studies = 4
  • Risk estimates = 4
    • (-) = 3
    • N = 1

Endometrial Cancer- main findings

  • 1 study reported.
    • CC: 28 cases and 140 controls
    • RE: (-)

Gastric/oral (Upper GI) Cancer- main findings

  • Data support a neutral relationship between plasma/serum lycopene concentrations and gastric/upper GI cancer risk.

Summary of studies and outcomes

  • Number of studies = 5
  • Risk estimates = 5
    • (-) = 2
    • N = 3

Lung Cancer- main findings

  • Data support a neutral relationship between plasma/serum lycopene concentrations and lung cancer risk.

Summary of studies and outcomes

  • Number of studies =3
  • Risk estimates = 3
    • N = 3

Ovarian Cancer- main findings

  • 2 Case-control studies reported
    • Number of cases (n= ≤ 100)

Summary of studies and outcomes

  • Number of studies = 2
  • Risk estimates (RE) = 2
    • (-) = 1
    • N = 1

Pancreatic Cancer- main findings

  • 1 Case-control study reported.
    • Number of cases (n= ≤ 100)
    • RE: (-)
  • Number of studies = 1
  • Risk estimates = 1
    • (-) = 1

 

Prostate Cancer- main findings

  • Data support a neutral, although potentially protective, relationship between plasma/serum lycopene concentrations and prostate cancer risk.
  • Genetic / SNP relationship with plasma/serum lycopene and aggressive prostate cancer risk.
  • All studies were Case-control (most nested in larger PC studies)

Summary of studies and outcomes

  • Number of studies = 15
  • Risk estimates (RE) = 19
    • (-) = 7
    • N = 4
    • (-)/N = 4