Cancer
Main Findings - Tomato/Tomato Based Foods and Disease Risk

Breast Cancer | Colorectal Cancer | Gastric/Oral (Upper GI) Cancer | Lung Cancer | Ovarian Cancer | Pancreatic Cancer | Prostate Cancer | Renal/Urothelial Cancer

Breast Cancer- main findings

  • Data support a neutral relationship between tomatoes/tomato product intake and breast cancer risk.

Summary of studies and outcomes

  • Number of studies = 3
  • Risk estimates (RE) = 3
    • (-) = 1
    • N = 2
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 1 (-)
    • √PT P. Tom = 2 (N)
    • √FT F. Tom = 0
    • √Lyco Lyco = 0

Colorectal Cancer- main findings

  • 2 studies reported
    • 1 case control study with > 1000 colorectal cancer patients.
      • RE: (-)
    • 1 RCT (n=22, Tom vs Carrot J,
      • RE: N
  • Data are mixed, limited and inconclusive.

Summary of studies and outcomes

  • Number of studies = 2
  • Risk estimates (RE) = 2
    • (-) = 1
    • N = 1
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 1 (-)
    • √PT P. Tom = 1 N
    • √FT F. Tom = 0
    • √Lyco Lyco = 0

Gastric/oral (Upper GI) Cancer- main findings

  • Data support a protective relationship between tomatoes/tomato product intake and gastric cancer risk.

Summary of studies and outcomes

  • Number of studies = 4
  • Risk estimates (RE) = 7
    • (-) = 7
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 3 (-)
    • √PT P. Tom = 1 (-)
    • √FT F. Tom = 2 (-)
    • √Lyco Lyco = 1 (-)

Lung Cancer- main findings

  • Data support a protective relationship between tomatoes/tomato product intake and lung cancer risk.

Summary of studies and outcomes

  • Number of studies = 6
  • Risk estimates (RE) = 6
    • (-) = 7
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 5 (-)
    • √PT P. Tom = 1 (-)
    • √FT F. Tom = 0
    • √Lyco Lyco = 0

Ovarian Cancer- main findings

  • Data support a neutral relationship between tomatoes/tomato product intake and ovarian cancer risk.

Summary of studies and outcomes

  • Number of studies = 2
  • Risk estimates (RE) = 2
    • (-) = 1
    • N = 1
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 1 (-)
    • √PT P. Tom = 1 (N)
    • √FT F. Tom = 0
    • √Lyco Lyco = 0

Pancreatic Cancer- main findings

  • 1 Case-control study reported.
    • Number of cases (n= ≤ 100)
    • RE: (-)
  • Number of studies = 1
  • Risk estimates = 1
    • (-) = 1

Pancreatic Cancer- main findings

  • Data are limited.
    • 1 Case-control study reported.
    • Number of cases (n= 201-500)
  • Number of studies = 1
  • Risk estimates (RE) = 1
    • (-) = 1
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 1 (-)
    • √PT P. Tom = 0
    • √FT F. Tom = 0
    • √Lyco Lyco = 0

Prostate Cancer- main findings

  • Data support a protective relationship between tomatoes/tomato product intake and prostate cancer risk.
  • The data also suggest that processed tomato intake may be the most beneficial in this protection compared to alternative categories of tomato intake (general or fresh).

Summary of studies and outcomes

  • Number of studies = 25
  • Risk estimates (RE) = 33
    • (-) = 24
    • N = 7
    • (+) = 2
  • Risk estimates by Tomato or Lycopene category
    • √GT G. Tom = 9 (-), 5 (N), 1 (+)
    • √PT P. Tom = 10 (-), 1 (N)
    • √FT F. Tom = 1 (-), 0 (N), 1 (+)
    • √Lyco Lyco = 4 (-), 1 (N)

Renal Cancer- main findings

  • 1 study reported.
    • CC study (n=335 cases, 1:1)
    • RE: (-)

Urothelial Cancer- main findings

  • 1 study reported.
    • PC study
    • RE: N