R E T U R N M E N U

Dietary Lycopene and
Disease Risk

Plasma/Serum Lycopene
and Disease Risk

Lycopene Supplementation
and Disease Risk

Tomato/Tomato-based foods
and Disease Risk

C R I T I C A L F I N D I N G S

Bladder Cancer
Breast Cancer
Cervical Cancer
Colorectal Cancer
Endometrial Cancer
Gastric/oral (Upper GI) Cancer
Head and Neck
Lung Cancer
Ovarian Cancer
Pancreatic Cancer
Prostate Cancer

CANCER
Plasma/Serum Lycopene and Disease Risk

Bladder Cancer- main findings

Data support a neutral relationship between serum lycopene and bladder cancer
1 CC study (n=242 cases, CC 1:1)
RE: N

Breast Cancer- main findings

Data support a neutral relationship between serum lycopene concentrations and breast cancer risk.
The positive (risk) findings require further investigation.

Summary of studies and outcomes

Number of studies = 15
Risk estimates (RE) = 15 (-) = 7
- N = 7
- (+) = 1

Cervical Cancer- main findings

Data support a neutral, although potentially protective, relationship between serum lycopene concentrations and cervical cancer risk.

Summary of studies and outcomes

Number of studies = 15
Risk estimates (RE) = 15
- (-) = 8
- N = 7

Colorectal Cancer- main findings

Data suggest a protective association between serum lycopene concentrations and colorectal cancer; however, the data are extremely limited, based on number and quality of investigations.

Summary of studies and outcomes

Number of studies = 4
Risk estimates (RE) = 4
- (-) = 3
- N = 1

Endometrial Cancer- main findings

1 study reported.
- CC: 28 cases and 140 controls
- RE: (-)

Gastric/Upper GI Cancer- main findings

Data support a neutral relationship between serum lycopene concentrations and gastric/upper GI cancer.

Summary of studies and outcomes

Number of studies = 6
Risk estimates (RE) = 6
- (-) = 2
- N = 4

Head and Neck Cancer- main findings

Data support a neutral relationship between serum lycopene concentrations and head and neck cancer.

Summary of studies and outcomes

Number of studies = 3
Risk estimates (RE) = 3
- (-) = 1
- N = 2

Lung Cancer- main findings

Data support a neutral relationship between serum lycopene concentrations and lung cancer.

Summary of studies and outcomes

Number of studies = 5
Risk estimates (RE) = 5
- N = 4
- (-) = 1

Ovarian Cancer- main findings

Data suggest a neutral relationship between serum lycopene concentrations and ovarian cancer.
- 2 Case-control studies reported
- Number of cases (n= ≤ 100)

Summary of studies and outcomes

Number of studies = 2
Risk estimates (RE) = 2
- (-) = 1
- N = 1

Pancreatic Cancer- main findings

Data are inconclusive.
- CC = 1, PC = 1
- Number of cases (n= ≤ 100) and > 1000, respectively

Summary of studies and outcomes

Number of studies = 2
Risk estimates (RE) = 2
- (-) = 2

Cancer Mortality - main findings

Data are inconclusive.
- CS, NHANES (n=13,293)

Summary of studies and outcomes

Number of studies = 1
Risk estimate
- (RE) = 1
- (N) = 1 25

Prostate Cancer- main findings

Data support a neutral, although potentially protective, relationship between serum lycopene concentrations and prostate cancer risk.
Genetic / SNP relationship with serum lycopene and (-) aggressive prostate cancer risk.

Summary of studies and outcomes

Number of studies = 20
Risk estimates = 25
- (-) = 12
- N = 12
- (+) = 1